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Commerce is a very active economic sector in the municipality. This sector contributes a substantial income to the municipality. This sector contributes a substantial income to the municipal coffers.

As of September 2016, there are 10,000 commercial and industrial firms operating in the municipality.

SM City Taytay is a shopping mall owned and operated by SM Prime Holdings. It is the first SM Supermall in the province of Rizal which is located in Manila East Road. It is consists of two buildings interconnected with a bridge featuring shops like SM Hypermarket, SM Department Store, SM Cinemas, SM Foodcourt, Watsons, SM Appliance Center, Ace Hardware and other various shops and restaurants.

In 2014, SM Prime announced the expansion of the mall, with a four-storey mix commercial and office building set to rise in the newly acquired lot adjacent to the mall. Now, the building is housing the first BPO Company in the town, together with various restaurants and a convenience store.

In 2016, the town's economy continue to boosts as different establishments like Puregold, the Hive, Toyota, Mitsubishi, Nissan, McDonalds, KFC, Jollibee, Max's and other huge local and foreign companies invest and eyeing the town as the Next Central Business District in the East.

Robinsons Companies are also conducting studies for the possibility of constructing another mall in the province. Coca Cola Inc., San Miguel Breweries, Megaworld, Sta. Lucia Realty, CityMall and Ayala Land have either planned or expanded its business portfolio in Taytay, citing reasons of economic viability, strong internal market and accessibility.

Club Manila East (CME) is another getaway destinations in the heart of the municipality of Taytay. The resort-hotel has a 9,100 sqm "Funtasy Lagoon" pool which is a scaled-down model of Laguna de Bay. The surrounding day-tour cabanas, good for up to 20 persons and complete with shower and bath are named after the surrounding towns of Laguna de Bay. CME, with Philippine Surfing Academy (PSA), also conducts surfing lessons in its two wavepools, the "Beachwaves" and the "Oceanwaves". The Oceanwaves is the biggest of its kind in the country with powerful waves rising up to 1.5 meters high. And through its "CME FLY", a 6-floor-high, 360-meter-long zipline, CME takes its guests to a high adrenaline level. The latest addition to the facilities of CME is the Beach Volleyball court. To date, CME has 70 overnight villas, and 4 big-room dormitories. It has various seminar and function facilities to accommodate 50 to 1,000 people. And to serve the food needs of its clients, the Doña Nelia Restaurant serves a wide range of Filipino and Continental dishes at very affordable prices.

Just this 2014, MySpace Properties, A Megawide Construction Corporation Subsidiary, has unveiled its newest mix-use commercial and residential complex along Ortigas Avenue in Barangay San Isidro, dubbed as The Hive Malls + Residences. The project sits beside Baltao compound and has a frontage of more than one hundred meters. It will host several commercial establishments and residential condominiums, providing a one-stop shop for Taytayenos who need not travel more to avail of some services and commercial goods. The project kicked off this October and is expected to be completed in the next one to two years.